Assessing Antiretroviral Activity: A Practical Guide to Selecting New Agents for Treatment-Experienced Patients

In this new Treatment Update, CCO’s expert faculty members discuss the latest findings from clinical studies regarding the role of HIV resistance and tropism data in designing new regimens for treatment-experienced patients. Case Vignettes provide practical examples of clinical scenarios that may be encountered in practice.

Now Available!

CME-Certified Case Vignette:

Treatment Options for a Patient With Persistent Viremia on Enfuvirtide-Containing Therapy Joseph J. Eron, Jr., MD, discusses assessment of treatment options for a patient with multidrug resistance failing an enfuvirtide-containing regimen.

CME-Certified Interactive Virtual Presentation:

Assessing Antiretroviral Activity: A Practical Guide to Selecting New Agents for Treatment-Experienced Patients  Watch, listen, and make treatment decisions as Charles B. Hicks, MD, leads you through this interactive presentation exploring the application of various tools and approaches, including resistance and tropism tests, to assess the activity of antiretroviral agents to individualize treatment for antiretroviral-experienced patients.

Downloadable Slideset:

Assessing Antiretroviral Activity: A Practical Guide to Selecting New Agents for Treatment-Experienced Patients  Charles B. Hicks, MD, discusses the latest findings from clinical studies regarding the impact of HIV resistance and tropism on the assessment of the antiretroviral activity of specific agents in designing new regimens for treatment-experienced patients.

Integrating New Antiretroviral Agents Into Therapeutic Strategies for Treatment-Experienced Patients

Watch, listen, and make treatment decisions as Eric S. Daar, MD, leads you through a series of interactive clinical scenarios exploring the use of the newly approved antiretroviral agents in virologically suppressive regimens for treatment-experienced patients.

Now Available!

CME-Certified Interactive Virtual Presentations:

New Therapeutic Strategies for Managing Treatment-Experienced Patients              Downloadable Slideset

Integrating New Antiretroviral Agents Into Therapeutic Strategies for Treatment-Experienced Patients              Downloadable Slideset

The Role of Integrase Inhibitors in HIV Management

Through a CME-certified video module and 3 downloadable slidesets, CCO’s expert faculty members explore key strategies for the effective use of integrase inhibitors in the context of the most recent clinical trials data and with consideration of mechanisms and consequences of resistance.

Now Available!

CME-Certified Video Module:

The Role of Integrase Inhibitors in HIV Management In this treatment update, Eric S. Daar, MD; Daniel R. Kuritzkes, MD; and Martin Markowitz, MD, discuss the role of the integrase enzyme in the HIV life cycle, clinical studies of integrase inhibitors, and the use of these agents in the management of HIV-infected patients.

Role of Integrase Enzyme This downloadable slideset reviews the mechanism of action of integrase inhibitors and explores how resistance may develop.

Clinical Trials of Integrase Inhibitors This downloadable slideset reviews the results of key clinical trials of integrase inhibitors.

Clinical Role of Integrase Inhibitors  This downloadable slideset reviews strategies for the use of integrase inhibitors in clinical practice.

CCO Independent Conference Coverage of the 2008 ICAAC/IDSA Annual Meeting

CCO's coverage of the 2008 ICAAC/IDSA Annual Meeting includes Capsule Summaries of key presentations, as well as Expert Analyses, Slides, Expert Recaps, and audio and video Expert Highlights that focus on key issues highlighted at the conference.

• Timing and Choice of First-Line Antiretroviral Therapy

• Management of Treatment-Experienced Patients

• Clinical Complications of HIV and Its Therapy

• Hepatitis and Opportunistic Coinfections

Managing HIV-Infected Patients With Initial Regimen Failure

This up-to-date Management Series provides an overview of the causes and consequences of treatment failure with first-line antiretroviral regimens as well as practical clinical strategies for avoiding and managing initial treatment failure in HIV-infected patients.

Now Available!

CME-Certified Interactive Case Challenges:

Choosing an Optimal Second-Line Regimen for a Patient With Intermittent Adherence Join Karam Mounzer, MD, in managing the care of an HIV-infected patient with erratic behavior and intermittent adherence.

Managing the Care of an HIV-Infected Patient With an Inaccurate Previous Treatment History Along with Peter J. Ruane, MD, choose management strategies for a challenging HIV-infected patient.

Understanding and Preventing Causes of Virologic Failure in Initial Therapy In this CME-certified module, Anthony M. Mills, MD, describes diverse causes of failure in treatment-naive patients, suggests which patients may have the highest risk of failure, and proposes practical guidelines for avoiding failure in clinical practice.

Consequences of Failure: Outcomes and Options After Failure of the Initial Antiretroviral Regimen Charles B. Hicks, MD, and Susanna Naggie, MD, discuss factors associated with initial treatment failure and summarize important considerations for tailoring optimal second-line regimens based on evidence from recent clinical trials.

Managing HIV-Infected Patients With Initial Regimen Failure This downloadable slideset includes a review of clinically relevant data important for preventing first-line antiretroviral failure and choosing subsequent regimens for patients with first-line virologic failure.

Also Available!

Initial Regimen Failure Pocket Guide:

Resistance Consequences of First-Line Antiretroviral Regimen Failure This downloadable Pocket Guide, developed by Joseph J. Eron, Jr., MD, provides a convenient reference outlining typical patterns and incidence of resistance after failure of DHHS and IAS-USA recommended first-line regimens in clinical studies.

CCO HIV Stay Tuned

Bimonthly CME-certified audio Podcasts, each supported by a variety of online resources.

Evolving Concepts in Antiretroviral Therapy—Volume 1, Edition 4 Watch and listen to CCO's expert faculty members discuss the current European guideline recommendations on when to start antiretroviral therapy and the potential clinical implications of data presented at the 2008 International AIDS Conference in Mexico City, Mexico. Then download audio, video, and slides for additional reference and use in your own talks. Click here to start.

Answering the Questions: HIV Tropism in Clinical Practice

Now Available!

CME-Certified Module:

HIV Journal Options - Volume 4, Issue 4

Topics include:

• Class-Sparing Regimens for Initial Treatment of HIV-1 Infection
• NRTIs and Risk of Myocardial Infarction
• CD4+ Cell Count-Guided Antiretroviral Treatment Interruption
• SMART: Major Clinical Outcomes
• Incidence of Types of Cancer Among HIV-Infected Persons
• Efavirenz-Based Regimens in Treatment-Naive Patients
• Impact of Stavudine Dose Reductions on Body Composition
• Durability and Outcome of Initial Antiretroviral Treatments

Answering the Questions: Practical Management Strategies to Address Cardiovascular Risk in HIV

CME-Certified Modules:

Also Available!

CCO Slideset
Answering the Questions: Practical Management Strategies for Cardiovascular Risk in HIV

Managing Insulin Resistance in HIV-Infected Patients

Now Available!

CME-Certified Interactive Case Challenge:

CME-Certified Module:

Downloadable Slideset:

Managing Dyslipidemia in HIV-Infected Patients on Therapy: Switch Antiretrovirals or Add Lipid-Lowering Agents?

Now Available!

Downloadable Audio and Slideset:

Managing Dyslipidemia in HIV-Infected Patients on Therapy Marshall J. Glesby, MD, PhD, and James H. Stein, MD, review evidence for managing HIV-infected patients with dyslipidemia—should one switch antiretroviral therapy or add lipid-lowering agents? Downloadable Audio and Slideset

CME-Certified Module:

Managing Dyslipidemia in HIV-Infected Patients on Therapy: Switch Antiretrovirals or Add Lipid-Lowering Agents? Marshall J. Glesby, MD, PhD, and James H. Stein, MD, review evidence, discuss cases, and answer questions on the strategy of switching antiretroviral therapy vs adding lipid-lowering drugs for managing HIV-infected patients with dyslipidemia.

2008 International AIDS Conference

CCO's official coverage of the 2008 International AIDS Conference includes Capsule Summaries of key presentations, as well as Expert Analyses, Slides, Expert Recaps, and audio and video Expert Highlights that focus on key issues highlighted at the conference.

• Timing and Choice of First-Line Antiretroviral Therapy

• Management of Treatment-Experienced Patients

• Clinical Complications of HIV and Its Therapy

• HIV Management in Women

• Treatment and Biomedical Prevention in Resource-Limited Settings

Now Available!

Highlights of the 2008 International AIDS Conference
Kathleen E. Squires, MD, discusses the highlights from the 2008 International AIDS Conference in this CME/CE-certified Expert Recap.

HIV/AIDS Annual Update 2008

Clinical Care Options' HIV/AIDS Annual Update offers the latest information across a wide range of issues for the optimal clinical management of your patients. Expert faculty members prepared the following CME-certified educational modules that are now available on the CCO Web site:

CME-Certified Modules:

• HIV Disease Pathogenesis and the Gastrointestinal Tract
• Eradication of HIV: Possible or Still a Pipe Dream?
• New Findings on Resistance to NRTIs, NNRTIs, and PIs
• Novel Antiretroviral Agents
• Clinical Strategies for Initiation of Antiretroviral Therapy
• Non−AIDS-Defining Cancers in the Era of HAART
• Neurologic Aspects of HIV Infection and Its Therapy
• Advances in HIV/HCV Coinfection
• The US HIV Epidemic: Why Is Prevention Failing?
• The Global HIV Epidemic: Updates on Epidemiology and Prevention
  

• 2008 ICAAC/IDSA Annual Meeting*
  
  
• 2008 International AIDS Conference
  
  
• 2008 Conference on Retroviruses and Opportunisitic Infections *
  
  
  
  
  

*CCO is an independent medical education company that provides state-of-the-art medical information to healthcare professionals through conference coverage and other educational programs.

• New Insights Into the Use of PIs Across the Treatment Spectrum
  Watch CME/CE-certified video of an expert faculty panel discussing how recent advances in the PI class may affect treatment decisions in patients with varying levels of antiretroviral experience.
  
  
• Novel Agents for Treatment-Experienced Patients: Faculty Mentoring for Managing Challenging Cases
  Join Sally Hodder, MD, Kimberly Y. Smith, MD, MPH, and Andrew R. Zolopa, MD, in this unique video classroom as they provide insight into the management of 2 unique complex cases involving treatment-experienced patients.
  
  
• Evolving Insights Into the Optimal Timing of Antiretroviral Therapy
  Paul E. Sax, MD, reviews the optimal timing of antiretroviral therapy in response to revised recommendations issued by the Department of Health and Human Services.
  
  
• Rethinking the Role of NNRTIs: Clinical Strategies for Optimizing Outcomes With Next-Generation Agents
  Joseph J. Eron, Jr., MD, discusses clinical data and strategies important for optimal use of next-generation NNRTIs in the management of HIV-infected patients. Access case vignettes by Joseph J. Eron, Jr., MD, Pablo Tebas, MD, and W. David Hardy, MD.
  
  
• Simple From the Start: The Importance of Treatment Convenience in Antiretroviral Therapy
  2 CME-certified modules by Edwin DeJesus, MD, FACP and 3 Interactive Case Chalenges
  

• Psychiatric Disorders in HIV-Infected Patients
  Review 2 educational modules and 3 case challenges.
  
  
  
• The Role of Integrase Inhibitors in HIV Management
  Review educational modules, case challenges and a downloadable slideset.
  
  
  

• Management of a 38-Year-Old Male on Methadone Maintenance Therapy Who Presents With PCP
  William G. Powderly, MD, discusses the selection of initial therapy for a 38-year-old recovering injection drug user male with HIV/hepatitis C virus coinfection who presents with Pneumocystis jirovecii pneumonia (PCP).
  
  
• Management of a 38-Year-Old Otherwise Healthy Married Man Recently Diagnosed With HIV Infection
  Edwin DeJesus, MD, FACP, discusses key concerns about the initiation of antiretroviral therapy for a 38-year-old busy professional man recently diagnosed with HIV.
  
  
• Management of a Moderately Treatment-Experienced Male Using Novel Antiretroviral Agents
  Andrew R. Zolopa, MD, discusses key issues in the management of a chronically infected patient with persistent viremia.
  
  
• Management of a Virologically Suppressed Patient Experiencing Injection-Site Reactions With His Current Regimen
  Jonathan M. Schapiro, MD, discusses management issues in the case of a treatment-experienced male who is experiencing intolerable adverse effects from his successful regimen.
  
  
• Management of a Patient With Extensive Antiretroviral Experience and Persistent Low-Level Viremia
  Edwin DeJesus, MD, FACP, discusses issues in managing a clinically stable male patient who has not been able to achieve undetectable HIV-1 RNA.
  
  
• From Theory to Practice: Strategies for the Successful Management of Treatment-Experienced Patients 
  Interesting Interactive Case Challenges and Commentaries that explore treatment decisions for antiretroviral-experienced patients.
  
  

Topics

• Adverse Effects and Comorbidities
• Antiretroviral Management
• Epidemiology and Natural History
• Opportunistic Diseases and Coinfection
• Pharmacology
• Resistance
• Special Populations

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IAS 2009 Registration and Abstract Submission Now Open!

The 5th IAS Conference on HIV Pathogenesis, Treatment and Prevention will take place from 19-22 July 2009 in Cape Town, South Africa. Online registration is now open at www.ias2009.org and participants are encouraged to register by 25 February 2009 to avoid a late fee surcharge.


The abstract submissions deadline for IAS 2009 is 25 February 2009. All abstracts must be submitted online through the conference website.


Online abstract mentoring, an opportunity for less experienced abstract submitters to ask questions of more experienced submitters, is available until 11 February. Click here for more information.

FEATURED VIDEO

New Agents

Joseph J. Eron, Jr., MD, describes new data on the investigational maturation inhibitor bevirimat and entry inhibitor PRO 140 and discusses the reanalysis of data from the MERIT trial. Click here to start.

FEATURED VIDEO SEGMENT
Update on the Management of Treatment-Experienced Patients From the 2008 International AIDS Conference

Joseph J. Eron, Jr., MD, summarizes key presentations from the 2008 International AIDS Conference that are likely to impact the management of treatment-experienced patients. Click here to start.

MERIT: Comparable Virologic Efficacy With Maraviroc vs Efavirenz in Antiretroviral-Naive Patients After Post Hoc Reanalysis Using Enhanced-Sensitivity Phenotypic Tropism Assay for Screening  

Excluding patients determined to have D/M-tropic virus at screening by enhanced phenotypic tropism assay, retrospective analysis revealed comparable virologic efficacy in maraviroc vs efavirenz groups, with fewer adverse event-related discontinuations with maraviroc

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