Clinical Care Options Hepatitis - Clinical Strategies for Preventing Drug Resistance in Chronic Hepatitis B Infection

Mechanisms of Resistance to Anti-HBV Agents

Module 1 of 2

Faculty:

Maria Buti, MD

CREDIT INFORMATION

Release Date: 01/28/09

Expiration Date: 01/27/10

Physicians: maximum of 0.75 AMA PRA Category 1 Credits™

Registered Nurses: 0.9 Nursing contact hours

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Maria Buti, MD, reviews the development of HBV antiviral resistance in context of the life cycle of HBV and the mechanisms of action of antiviral drugs.

Learning Objectives

Upon completion of this activity, participants should be able to:

Discuss the mechanisms by which HBV may develop resistance to antiviral therapy
Explain how viral mutations that confer resistance to one anti-HBV agent may also cause cross-resistance to other agents
Describe clinical strategies that may minimize the risk of developing drug-resistant HBV

Abstract

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Preventing Nucleos(t)ide Resistance in Treatment-Naive Patients

Module 2 of 2

Faculty:

Marc G. Ghany, MD

CREDIT INFORMATION

Release Date: 03/05/09

Expiration Date: 03/04/10

Physicians: maximum of 1.0 AMA PRA Category 1 Credit™

Registered Nurses: 1.0 Nursing contact hour

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Marc G. Ghany, MD, discusses oral agents for the treatment of chronic hepatitis B, their potency, and barriers to resistance and how this impacts the selection of initial treatment regimens.

Learning Objectives

Upon completion of this activity, participants should be able to:

Recount the results of clinical studies of oral treatments for HBeAg-positive, HBeAg-negative, and HBV treatment–naive patients
Describe the differences in potency between currently available oral agents and highlight the importance of potency in prevention of HBV resistance
Identify management strategies that may reduce the risk of hepatitis B virus resistance

Abstract

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Disclaimer: The materials published on the Clinical Care Options Web site reflect the views of the reviewers or authors of the CCO material, not those of Clinical Care Options, LLC, the CME provider, or the companies providing educational grants. The materials may discuss uses and dosages for therapeutic products that have not been approved by the United States Food and Drug Administration. A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or using any therapies described in these materials.